The Small Molecule Drug Development Shared Resource (SR) optimizes robust assays in 384-well format and to screen large chemical libraries to identify new small molecules for innovative cancer therapeutics.
Location
Case Western Reserve University School of Medicine
Biomedical Research Building 747
2109 Adelbert Rd, Cleveland, OH 44106
Services
| Service/Expertise | Cost | Description |
|---|---|---|
| Initial consultation | None | Investigators receive feedback regarding assay development/HTS goals, while Director and Managing Director suggest optimal assay approaches |
| Training: Facility Orientation | None | 1-hr session covering all instruments |
| Training: Operetta microscope, or Cytation5 microscope |
$400 |
Two 2-hr sessions covering imaging, data storage and analysis |
| Operetta microscope, or Cytation5 microscope, hourly usage |
$30/hour |
Enables investigators to benefit from automated imaging including live cell systems |
| Image analysis on a remote server |
None |
Allows investigators to benefit from high throughput image analysis |
| Access to automated dispensers and washers |
None |
Provides investigators with access to high data density experimentation |
| Managing Director support | $100/hour | General support in assay development and execution |
| Bioactives Library access (3,200 cpds) | $400 |
Enables pilot screening, pathway elucidation and drugs repurposing |
| HTS Library access (100,000 molecules) |
$4,000 | Enables HTS and drug discovery |
| All-inclusive screening packages |
Quotes available |
Enables dedicated % effort from Managing Director, library access, and equipment time. Can include consumables and reagent costs. Priced on a per-project basis due to varying assay needs. |
Available Instruments
Synergy NEO2 plate reader ( Biotek/Agilent)
Operetta automated microscope (Perkin Elmer)
EL406 washer/dispenser (Biotek/Agilent)
MultiFLo dispenser (Biotek/Agilent)
Janus MDT liquid handling platform with 50nL 384 pin tool (Perkin Elmer, V&P Scientific)
Contact for More Information
Drew Adams, PhD, Director
216.368.4922
dja59@case.edu
Yuriy Fedorov, PhD, Managing Director
216.368.1506
yuriy.fedorov@case.edu